post Graduate Program in Translational Biomedicine - BIOTRANS

Presentation

Goals

• (i) Introduce the precepts of Translational Biomedicine so that students acquire knowledge and experience on the two-way interactions of knowledge and practice between the cellular and molecular biology and the clinic, making them more agile and effective;
• (ii) Focus on the systematic acquisition of knowledge in Biosciences oriented to the physiology of organs and systems of the omic era: genomes, transcriptomes, hybridomes, proteomes, metabolomes, kinomes, spormes and interatomes;
• (iii) Present to graduate students an updated version of the concept of highly prevalent multifactorial diseases and neglected diseases and their relationship with Translational Biomedicine; the objective is to direct such information to the physiology and pathophysiology of organs and systems involved in the genesis of these diseases and to point to new therapeutic approaches (drugs, biopharmaceuticals) and new technologies (tissue bioengineering);
• (iii) Acquire, through the reading of texts, book chapters, journal articles, expanded abstracts and videoconferences, critical posture in the interpretation of current and new information and consistent questions, under the permanent guidance of a teacher. Active methodologies are used during classes, such as case reports, magazine clubs and others;
• (iv) Train post-graduate students to write scientific papers, dissertations, articles and abstracts for events in English, making audiovisual communication materials (slides, videos);
• (v) Raising awareness of the Program's graduate students about the importance of acting as vectors for the dissemination of scientific experiences and information among the general public in the region, contributing to their popularization.

Curricular Options

Concentration Areas

• From Biological Systems to Translational Biomedicine

Translational Biomedicine proposes transferring (translating) knowledge from Physiology, Biochemistry, Molecular Biology and Cell Biology (in vitro, in vivo and in silico studies) to the clinical scenario (bedside, outpatient clinics, where the clinician and clinical investigator work), targeting the formation of graduate students in Life Sciences. The program encompasses: (i) the development of new methods of early diagnosis, including biomarkers and bioimaging; (ii) the formulation of proposals for innovative therapeutic solutions, including new drugs, cell therapy and bioengineered products; (iii) fostering knowledge of health status deviations, in a phase that precedes the emergence of symptoms above the clinical horizon - critical analysis of the results of studies with experimental models and clinical and epidemiological studies on the participation of risk factors and possible interactions with individual genetic predisposition.

The concentration area “From Biological Systems to Translational Biomedicine” aims, therefore, to rescue the interactive dialogue between cellular and molecular biology with the clinical researchers, promoting the reverse movement "from clinic to bench". Graduates of the program will have an interdisciplinary training with an emphasis on: (i) cellular and molecular biology, physiology, pathophysiology, molecular genetics; (ii) in the investigation of elements of early diagnosis; (iii) proposing innovative therapeutic solutions, such as those arising from tissue bioengineering. Pre-clinical studies (in experimental models) and clinical trials, Phase 1 (in humans), which will emerge clearly defined outcomes from these protocols. With that training, graduates will be able to understand, at the cellular and molecular levels, the pathophysiological mechanisms of multifactorial and neglected diseases.

Research lines

• Bioimage

The Bioimaging (BI) line encompasses research projects aimed at researching organ metabolism, the biological behavior of biomaterials (when in function) and their roles (in a translational perspective) in pre-clinical studies and clinical evaluation trials adverse effects and drug efficacy outcomes. The research line includes research and innovation projects with different and combined BI approaches. These projects include cellular and molecular studies of nuclear magnetic resonance, computed (micro) tomography, ultrasound, spectroscopy and voltage diffuser image, optical microscopy, scanning, transmission and confocal electronics, and positron emission tomography.

Concentration Area: From Biological Systems to Translational Biomedicine

Professors: Adalberto Ramon Vieyra, Alexander Machado Cardoso, Cláudia Maria Pereira, Eidy de Oliveira Santos, Fabio da Silva de Azevedo Fortes, Jose Mauro Granjeiro, Leandra Santos Baptista, Sergio Henrique Seabra, Victor Talarico Leal Vieira

• Biomarkers

Biomarkers (BM) include two categories, namely biological and image. Biological BMs are the expression of cellular and genetic-molecular mechanisms (including mutations and polymorphisms), and the dysfunction of tissues, organs and systems. BM by image characterizes morphological, functional and metabolic changes. This research line includes projects that investigate molecules, supramolecular structures and bioimaging tools involved in the early recognition of deviations in health status and anticipation of therapeutic response, in a translational perspective. The line also includes projects aimed at: (i) expanding critical knowledge about the function of biomarkers, such as immunometabolic proteins, cytokines, microRNAs, genetic variants that affect the therapeutic response, somatic factors for multifactorial diseases, tumor antigens and classification molecular tumor; and (ii) to investigate morphofunctional modifications such as those resulting from the interaction of parasites with the microenvironment of tissues and organs, and those resulting from responses to drugs and bioengineered products (stem cells in natural and synthetic frameworks).

Concentration Area: From Biological Systems to Translational Biomedicine

Professors: Adalberto Ramon Vieyra, Alexander Machado Cardoso, Cláudia Maria Pereira, Daniel Escorsim Machado, Eidy de Oliveira Santos, Fabio da Silva de Azevedo Fortes, Leandra Santos Baptista, Pedro Hernan Cabello Acero, Sergio Henrique Seabra