The PhD degree of the post-graduate program in experimental and dental clinic (ODONTOCLINEX) presents fields of interest in the biological systems, materials, instruments and techniques of dental use as well as its relationships with translational and clinical science.
ODONTOCLINEX is conceived with multidisciplinary and transdisciplinary bases that, articulated, link the concentration area, research lines, and subjects from the curricular matrix, obtaining a holistic approach with a wide scope studying contemporary and frontier themes in the area of Dentistry.
An only area of concentration, which projects the course's name, the knowledge and formation activities converges and integrate themselves in a flexible and personalized matrix of doctorates able to transit in the contemporary odontology.
The research lines are articulated among themselves with a diversified set of disciplines, including projects of stomatognathic repercussions of systemics process as cellular and molecular aspects of inflammation, pain and malignant degeneration, advancing by the new field of metabolic diagnosis in saliva.
In their practical and theoretical dimensions, these aspects are still projected to investigate and develop new therapeutic as offered by the instruments and materials from different origins and their mechanical and biological interaction with tooth, bone, and tissues.
Thus, the integration of research and dental clinical practice can be found in the research projectiles inserted in the concentration area to approach familiar risk factors, environmental factors, oral microbiota composition, and the genetic predisposition to identify biomarkers to develop translational odontology based on evidence and science.
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This research line has projects studying the biological features (biocompatibility and bioactivity) and the physical-chemistry properties (mechanical, structural, microstructural, and of surfaces) of dental materials. The research line includes projects which investigate the structure and biomechanical behavior of dental tissue in front of the materials and techniques during clinical procedures. In this line, simulation and analysis by finite element analysis are used in mathematical models; imaging methods including microcomputed tomography; biochemistry evaluations; mechanics essays; extesiometry and photoelasticity techniques in experimental models as well as clinical studies.
The research line in oral physiopathology involves projects that evaluate physiopathology repercussions in the mouth in front of pathogens and microbial interaction. That includes projects about epidemiologic aspects of cancer as well as the most incidence diseases of oral cavity using molecular markers (genes and microRNAs) expressed by various diseases.
Patients with oral disease (periodontal disease, pulp inflammatory disease, benign and malign tumors) will be evaluated by methodologies as cellular culture; microbiology investigation and molecular analysis (PCR, qPCR), DNA methylation and genome sequence. Besides, there are investigations using biomarkers changed comparing with clinical data of the patients in order to determine the early diagnosis and prognosis.
